How to get from Shinjuku to Osaka by car, truck, walk, bike

Distance between Shinjuku and Osaka is 398 kilometers (247 miles).
Driving distance from Shinjuku to Osaka is 505 kilometers (313 miles)

ShinjukuOsaka
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Route Map

4 Ways from Shinjuku (Japan/Tokyo) to Osaka (Japan/近畿 (Kinki Region))

Choose 1 of the options below and start your journey

Route instructions

1. Continue onto 区役所通り 85 m
2. Turn right onto 靖国通り, 302 399 m
3. Turn left onto 四谷角筈線, 414 579 m
4. Turn right onto 甲州街道, 20 948 m
5. Keep left onto 甲州街道, 20 240 m
6. Turn left onto 山手通り, 317 610 m
7. Keep right 2.67 km
8. Keep right onto 首都高速中央環状線, C2 1.15 km
9. Keep left 13.14 km
10. Keep left onto 東名高速道路, E1 84 m
11. Keep right 51.38 km
12. Keep left onto 東名高速道路(左ルート), E1 29.90 km
13. Keep left onto 新東名高速道路 256.26 km
14. Keep left 291 m
15. Keep right 29.06 km
16. Keep left 24.62 km
17. Keep left 2.96 km
18. Keep left 90.34 km
19. Keep left 266 m
20. Keep right 55 m
21. Turn slight left onto 内北浜通り 68 m
22. Turn right onto 四つ橋筋 280 m
23. Turn right onto 中之島通 475 m
24. Turn right onto 御堂筋, 25, 26, 165 55 m
25. Arrive at destination 0 m
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Questions and Answers

What is the cheapest way to get from Shinjuku (Japan/Tokyo) to Osaka (Japan/近畿 (Kinki Region))?
How do I get from Shinjuku (Japan/Tokyo) to Osaka (Japan/近畿 (Kinki Region)) the fastest?
How long does it take to get from Shinjuku (Japan/Tokyo) to Osaka (Japan/近畿 (Kinki Region))?