How to get from Myrtle Beach to Knoxville by car, truck, walk, bike
Distance between Myrtle Beach and Knoxville is 524 kilometers (325 miles).
Driving distance from Myrtle Beach to Knoxville is 653 kilometers (405 miles)
Route Map
Routes from myrtle-beach-south-carolina to knoxville-tennessee
4 Ways from Myrtle Beach (United States/South Carolina) to Knoxville (United States/Tennessee)
Choose 1 of the options below and start your journey
Cheapest
Fastest
Route instructions
1. Continue onto 8th Avenue North 76 m
2. Turn left onto Cedar Street 107 m
3. Turn right onto US 501 9.47 km
4. Turn sharp left onto US 501 12.87 km
5. Keep right onto Church Street, US 501, US 701 79.13 km
See more
Questions and Answers
What is the cheapest way to get from Myrtle Beach (United States/South Carolina) to Knoxville (United States/Tennessee)?
How do I get from Myrtle Beach (United States/South Carolina) to Knoxville (United States/Tennessee) the fastest?
How long does it take to get from Myrtle Beach (United States/South Carolina) to Knoxville (United States/Tennessee)?
Trips from Myrtle Beach
Myrtle BeachLexingtonMyrtle BeachDubuqueMyrtle BeachGreensboroMyrtle BeachTiftonMyrtle BeachSalinasMyrtle BeachEverettMyrtle BeachLincolnMyrtle BeachTallahasseeMyrtle BeachKingstreeTrips to Knoxville (United States/Tennessee)
Santa CruzKnoxvilleFresnoKnoxvilleEdenKnoxvilleFlorenceKnoxvilleConwayKnoxvilleBostonKnoxvilleAlpineKnoxvilleJacksonvilleKnoxvilleUticaKnoxvilleOther interesting routes
GeorgiaKentuckyNorth CarolinaSouth CarolinaTennesseeVirginiaGeorgiaSouth CarolinaInformation about Stations
All station in Myrtle Beach (United States/South Carolina)
Myrtle Beach Train Depot All station in Knoxville (United States/Tennessee)
Three Rivers Rambler KnoxvilleJackson Terminal Knoxville Station